Magic mushrooms have been used in traditional ceremonies and for recreational purposes for thousands of years. However, a new study has found that mushrooms evolved the ability to make the same psychoactive substance twice. The discovery has important implications for both our understanding of these mushrooms’ role in nature and their medical potential.

Magic mushrooms produce psilocybin, which your body converts into its active form, psilocin, when you ingest it. Psilocybin rose in popularity in the 1960s and was eventually classed as a Schedule 1 drug in the US in 1970, and as a Class A drug in 1971 in the UK, the designations given to drugs that have high potential for abuse and no accepted medical use. This put a stop to research on the medical use of psilocybin for decades.

But recent clinical trials have shown that psilocybin can reduce depression severity, suicidal thoughts, and chronic anxiety. Given its potential for medical treatments, there is renewed interest in understanding how psilocybin is made in nature and how we can produce it sustainably.

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Origianl Creator:
Fabrizio Alberti, The Conversation

Original Link: https://arstechnica.com/science/2025/10/how-different-mushrooms-learned-the-same-psychedelic-trick/
Originally Posted: Sat, 04 Oct 2025 11:00:07 +0000